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Clinical trials form an essential part of the overall drug development process, evaluating the safety and efficacy of a drug candidate. Studies suggest that around 40% of the total investment made for the development of a drug candidate is dedicated to clinical trials. However, the conduct of such trials is often fraught with challenges, including scientific and operational complexity, concerns associated with recruitment and retention of suitable patients, issues related to data handling and increasingly stringent regulatory guidelines. Further, owing to the inherent complexity of the overall process and involvement of several different stakeholders, these trials are prone to delays. It is worth mentioning that around 80% of the clinical trials are delayed due to insufficient patient recruitment. To request a sample copy / brochure of this report, please visit https://www.rootsanalysis.com/reports/245/request-sample.html Further, retaining patients is also a major concern in pharmaceutical research and development; 15% to 40% of the enrolled patients drop out before the studies are completed, significantly impacting product approvals / launch timelines. Therefore, patient outreach, recruitment and retention strategies have evolved significantly, especially with the availability of a variety of digital data generation, management and marketing solutions. In fact, a number of modern technology-enabled offerings are now available to support various aspects of clinical research and patient recruitment. Several players do not have dedicated patient enrolment teams and lack the necessary capabilities / expertise to successfully recruit desired number of patients in clinical trials. In some cases, the clinical studies are too large or geographically broad to be managed by internal staff. Further, the stringent ethical and regulatory guidelines associated with patient enrollment in trials impose a significant burden on drug developers. As a result, outsourcing has become a popular operating model with regards to patient retention. The advantages of engaging contract service providers are numerous and enable sponsors to meet their clinical research timelines and thereby, launch respective offerings as planned. Presently, more than 155 companies have the required capabilities to offer patient recruitment services and patient retention services across different geographical locations. For additional details, please visit link https://www.rootsanalysis.com/reports/view_document/patient-recruitment-and-retention-services-market/245.html or email [email protected] You may also be interested in the following titles: Gene Therapy Market: Industry Trends and Global Forecast, 2022-2035 3D Cell Culture Market (4th Edition): Industry Trends and Global Forecast, 2022-2035 About Roots Analysis Roots Analysis is one of the fastest growing market research companies, sharing fresh and independent perspectives in the bio-pharmaceutical industry. The in-depth research, analysis and insights are driven by an experienced leadership team which has gained many years of significant experience in this sector. Contact: Ben Johnson +1 (415) 800 3415 [email protected]

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Rise in clinical research activity for genetically modified therapies has resulted in the increase in demand for vectors, offering lucrative opportunities to players having capabilities for in-house and contract manufacturing of various types of vectors. Roots Analysis has announced the addition of “Viral Vector, Non-Viral Vector and Gene Therapy Manufacturing Market (5th Edition), 2022-2035” report to its list of offerings. Over the past few years, cell and gene therapies have gained significant popularity owing to their therapeutic potential. In fact, more than 20 genetically modified therapies have already been approved, which has resulted in the increase in demand for vectors, which have proven to be highly efficient for the delivery of genetic material to the targeted area. In order to cater to the growing demand, several companies are offering diverse range of services for vector and gene therapy manufacturing. The viral vector manufacturing and non-viral vector manufacturing landscape features a mix of industry players (well-established companies, mid-sized firms and start-ups / small companies), as well as several academic institutes. Key Market Insights More than 140 stakeholders claim to manufacture viral and non-viral vectors The market is currently dominated by the presence of various mid-sized industry players (50%); of these 57% of players are contract manufacturers, whereas 22% of players are in-house manufacturers. Over the time, several advancements have been made for the development of vector based technological platforms Majority (37%) of the available technologies are currently used in vector manufacturing followed by those available for manufacturing of cell and gene therapies (16%). Further, 53% of the vector-based technologies are dedicated for the development and manufacturing of adenoviral vectors. More than 295 partnerships were established between different stakeholders during the last decade Close to 55% partnerships have been reported post 2018, wherein, maximum partnerships were recorded in year 2022 (till May). Further, maximum partnerships were related to manufacturing (23%) followed by licensing agreement (20%) and product development agreement (15%). Close to 120 expansion activities have been recorded till 2022, growing at a CAGR of 10% Majority of the expansions in this domain were related to the establishment of new facility (39%) followed by facility expansion (12%). The installed vector manufacturing capacity is estimated to be ~186,150 L Majority (70%) of total installed capacity is currently available for clinical / commercial stage manufacturing of viral vectors. Further, players headquartered in North America (56%) have the highest installed capacity, across the globe. Till 2035, the annual demand for vectors is expected to grow at an annualized rate of 11% Currently, North America and Europe contribute to more than 70% of the demand for viral and non-viral vectors. By 2035, the demand, in terms of number of patients in clinical and commercial stage, demand for vectors, is projected to be ~ 400 thousand patients. The market is anticipated to grow at a significant rate, during the period 2022-2035 The majority share of service revenues is anticipated to come from vector manufacturing projects focused on oncological disorders (51%). By 2035, Europe is likely to capture the major share (42%) of the market followed by North America (30%) and Asia-Pacific (23%). To request a sample copy / brochure of this report, please visit link https://www.rootsanalysis.com/reports/274/request-sample.html Key Questions Answered  Who are the leading players (contract service providers and in-house manufacturers) engaged in the development of vectors and gene therapies?  Which regions are the current manufacturing hubs for vectors and gene therapies?  Which type of technologies are presently offered / being developed by the stakeholders engaged in this domain?  Which companies are likely to partner with viral and non-viral vector contract manufacturing service providers?  Which partnership models are commonly adopted by stakeholders engaged in this industry?  What type of expansion initiatives are being undertaken by players in this domain?  Which are the emerging viral and non-viral vectors used by players for the manufacturing of genetically modified therapies?  What are the opportunities and threats for the stakeholders engaged in this industry?  What is the current, global demand for viral and non-viral vector, and gene therapies?  How is the current and future market opportunity likely to be distributed across key market segments? By 2035, the financial opportunity within the viral vector, non-viral vector and gene therapy manufacturing market has been analyzed across the following segments:  Scale of Operation  Lab  Clinical  Commercial  Type of Vectors  AAV  Adenoviral  Lentiviral  Retroviral  Plasmid DNA  Other Vectors  Application Area  Gene Therapy  Cell Therapy  Vaccines  Therapeutic Area  Oncological Disorders  Rare Disorders  Neurological Disorders  Sensory Disorders  Metabolic Disorders  Musco-skeletal Disorders  Blood Disorders  Immunological Diseases  Others  Geographical Regions  North America  Europe  Asia Pacific  Latin America  MENA  Rest of the World The report also features inputs from eminent industry stakeholders, according to whom, the anticipated increase in demand for cell and gene therapies, is the most prominent driver of the growth of the vector supply market. The report includes detailed transcripts of discussion held with prominent industry representatives:  Menzo Havenga (Chief Executive Officer and President, Batavia Biosciences)  Nicole Faust (Chief Executive Officer & Chief Scientific Officer, CEVEC Pharmaceuticals)  Jeffrey Hung (Former Chief Commercial Officer, Vigene Biosciences)  Cedric Szpirer (Former Executive & Scientific Director, Delphi Genetics)  Olivier Boisteau, (Co-Founder / President, Clean Cells), Laurent Ciavatti (Former Business Development Manager, Clean Cells) and Xavier Leclerc (Head of Gene Therapy, Clean Cells)  Alain Lamproye (Former President of Biopharma Business Unit, Novasep)  Joost van den Berg (Former Director, Amsterdam BioTherapeutics Unit)  Bakhos A Tannous (Director, MGH Viral Vector Development Facility, Massachusetts General Hospital)  Eduard Ayuso, DVM, PhD (Scientific Director, Translational Vector Core, University of Nantes)  Colin Lee Novick (Managing Director, CJ Partners)  Semyon Rubinchik (Scientific Director, ACGT)  Astrid Brammer (Senior Manager Business Development, Richter-Helm)  Marco Schmeer (Project Manager, Plasmid Factory) and Tatjana Buchholz (Former Marketing Manager, Plasmid Factory)  Brain M Dattilo (Business Development Manager, Waisman Biomanufacturing)  Beatrice Araud (ATMP Key Account Manager, EFS-West Biotherapy)  Nicolas Grandchamp (R&D Leader, GEG Tech)  Géraldine Guérin-Peyrou (Director of Marketing and Technical Support, Polypus Transfection)  Naiara Tejados, Head of Marketing and Technology Development, VIVEBiotech)  Jeffery Hung (Independent Consultant) The research includes profiles of key players (listed below), featuring a brief overview of the company, its financial performance (if available), information related to its manufacturing facilities, proprietary vector manufacturing technology and an informed future outlook.:  Advanced BioScience Laboratories  Aldevron  Audentes Therapeutics  BioNTech Innovative Manufacturing  BioReliance  Biovian  bluebird bio  Cell and Gene Therapy Catapult  Celonic  Centre for Process Innovation  Cobra Biologics  Emergent BioSolutions  FinVector  FUJIFILM Diosynth Biotechnologies  Kaneka Eurogentec  Lonza  MeiraGTx  MolMed  Novasep  Orchard Therapeutics  Oxford BioMedica  Richter-Helm  Sanofi  Spark Therapeutics  Thermo Fisher Scientific  uniQure  Vibalogics  Vigene Biosciences  VIVEbiotech  Wuxi AppTech For additional details, please visit link https://www.rootsanalysis.com/reports/view_document/viral-vectors-non-viral-vectors-and-gene-therapy-manufacturing-market-/274.html or email [email protected] You may also be interested in the following titles: 1. 3D Cell Culture Market (4th Edition): Industry Trends and Global Forecast, 2022-2035 2. Gene Therapy Market: Industry Trends and Global Forecast, 2022-2035 About Roots Analysis Roots Analysis is one of the fastest growing market research companies, sharing fresh and independent perspectives in the bio-pharmaceutical industry. The in-depth research, analysis and insights are driven by an experienced leadership team which has gained many years of significant experience in this sector. Contact: Ben Johnson +1 (415) 800 3415 [email protected]

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Owing to the fact that a number of ADC developers are outsourcing various aspects of their business processes, CMOs engaged in this domain have undertaken several expansion initiatives to become one-stop-shops to cater to the diverse needs of ADC developers. London Roots Analysis has announced the addition of “ADC Contract Manufacturing Market (5th Edition), 2022-2035” report to its list of offerings. In order to mitigate the challenges associated with Antibody Drug Conjugate manufacturing, around 70-80% of the therapeutics developers prefer to outsource their operations to contract manufacturing organizations (CMOs), which claim to have the required expertise and experience to leverage their capabilities and yield cost savings opportunities. To request a sample copy / brochure of this report, please visit https://www.rootsanalysis.com/reports/218/request-sample.html Key Market Insights Presently, more than 30 players claim to offer ADC contract manufacturing services This segment of the industry is dominated by the presence of large (more than 501 employees) and mid-sized (51-500 employees) players, which collectively represent more than 80% of the total contract manufacturers in this domain. In addition, around15% firms were established post 2010. More than 84 expansions were reported in this industry, during 2012-2021 Of the total, 57% instances were focused on enhancing dedicated capabilities and capacities, followed by those carried out for the expansion / establishment of manufacturing facilities (42%). Partnership activity in this domain has increased at a CAGR of over 16%, during 2016- 2021 Manufacturing agreements emerged as the most popular type of partnership model adopted by industry stakeholders (18%), followed by product development agreements (16%) and research agreements (15%). Further, most of the deals were inked by players based in Europe (46%). Global, installed ADC contract manufacturing capacity is currently estimated to be close to 33 Kilograms The maximum share of the current installed capacity is expected to be captured by large players. Moreover, close to 37% of the installed manufacturing capacity is available in the Asia-Pacific region. 140,200+ patients have been enrolled in over 714 clinical trials, worldwide Clinical research activity, in terms of number of trials registered, is reported to have increased at a CAGR of 21%, in the past three years. Of the total number of trials, close to 47% of the studies are recruiting patients, while 30% have been completed. Global demand for ADC contract manufacturing is anticipated to grow at a CAGR of 13%, during 2022-2035 The commercial demand for ADC therapeutics is projected to increase at a CAGR of 22%. Further, the clinical demand for ADC therapeutics in phase III trials is projected to increase at a CAGR of 10%. The market is anticipated to grow at a CAGR of nearly 13%, during the period 2022-2035 In terms of type of cancer, ADC therapeutics targeting solid tumors (48%) are anticipated to capture the highest share; this trend is unlikely to change in the foreseen future. Further, based on type of antibody isotype, majority of the revenue share (90%) of the overall market is likely to be driven by IgG1 antibodies. While the focus has been on forecasting the market till 2035, the report also provides our independent view on various technological and non-commercial trends emerging in the industry. This opinion is solely based on our knowledge, research and understanding of the relevant market gathered from various secondary and primary sources of information. For additional details please visit https://www.rootsanalysis.com/reports/view_document/adc-contract-manufacturing-market/218.html or email [email protected] You may also be interested in the following titles: 1. Targeted protein degradation market, 2022-2035 2. Single-Use Upstream Bioprocessing Technology / Equipment Market, 2022-2035 About Roots Analysis Roots Analysis is one of the fastest growing market research companies, sharing fresh and independent perspectives in the bio-pharmaceutical industry. The in-depth research, analysis and insights are driven by an experienced leadership team which has gained many years of significant experience in this sector. Contact: Ben Johnson +1 (415) 800 3415 +44 (122) 391 1091 [email protected]

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